I tried with this:
#include <tunables/global>
/usr/bin/wine {
#include <abstractions/base>
#include <abstractions/user-tmp>
deny /bin/**.exe rwx,
deny /boot/**.exe rwx,
deny /dev/**.exe rwx,
deny /etc/**.exe rwx,
deny /lib/**.exe rwx,
deny /lib64/**.exe rwx,
deny /mnt/**.exe rwx,
deny /opt/**.exe rwx,
deny /proc/**.exe rwx,
deny /root/**.exe rwx,
deny /run/**.exe rwx,
deny /sbin/**.exe rwx,
deny /src/**.exe rwx,
deny /tmp/**.exe rwx,
deny /usr/**.exe rwx,
deny /var/**.exe rwx,
deny /home/myuser/Downloads/**.exe rwx,
deny /home/myuser/Documents/**.exe rwx,
deny /home/myuser/Pictures/**.exe rwx,
deny /home/myuser/Desktop/**.exe rwx,
/home/myuser/.wine/dosdevices/c:/myusers/myuser/My\ Documents/New\ Folder\ -\ For\ \(myuser\)/** r,,
/home/myuser/.wine/dosdevices/c:/myusers/myuser/My\ Documents/New\ Folder\ -\ For\ \(myuser\)/*.exe rix,
}
and i can open exe on allow ed folder, but i also can in Download folder. I change it to .wine instead of wine-stable , cause when i right click to that exe i opening it with opstion "Open with Wine Windows Program Loader".